Youpeng Wang#, Xingfeng Qiu#, Qinghai Li#, Jiale Qin, Lvlan Ye, Xiang Zhang, Xingxiang Huang, Xiangqiong Wen, Ziyang Wang, Weiling He*, Yuqin Di*, Qi Zhou*

Journal of Translational Medicine.2025.23(1):175

DOI：10.1186/s12967-025-06103-3

Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers

Kai Li#, Xuan Yu#, Yanteng Xu#, Haixia Wang, Zheng Liu, Chong Wu, Xing Luo, Jiancheng Xu, Youqiang Fang, Enguo Ju, Shixian Lv, Hon Fai Chan, Yeh-Hsing Lao, Weiling He*, Yu Tao*, Mingqiang Li*

Nature Communications.2025.16(1):1629

DOI：10.1038/s41467-025-56407-7

Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach

Chuwei Liu#, Heng Liang#, Arabella H Wan#, Min Xiao#, Lei Sun#, Yiling Yu, Shijia Yan, Yuan Deng, Ruonian Liu, Juan Fang, Zhi Wang*, Weiling He*, Guohui Wan*

Nature Communications.2025.16(1):798

DOI：10.1038/s41467-025-56173-6

Cystine-Modified Lignin-Copper Coordination Nanocarriers Improve the Therapeutic Efficacy of Tyrosine Kinase Inhibition via Cuproptosis

Shiyao Song#, Xingfeng Qiu#, Shaoqing Huang#, Huixuan Tian, Ruihan Pu, Jingyi Huang, Jiayin Su, Yan-Lai Tang, Libin Huang, Xuequn Luo, Weiling He*, Qingfeng Ni*, Weijing Zhang*

ACS Appl Mater Interfaces.2025.17(6):9074-9086

DOI：10.1021/acsami.4c20305

NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer

Ziyang Wang#, Yuqin Di, Xiangqiong Wen, Ye Liu, Lvlan Ye, Xiang Zhang, Jiale Qin, Youpeng Wang, Huiying Chu, Guohui Li, Weijing Zhang, Xiongjun Wang, Weiling He*

Science Translational Medicine.2024.16(774):eado8333

DOI：10.1126/scitranslmed.ado8333

UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling

Mei Song#, Shuting Huang, Xiaoxue Wu, Ziyi Zhao, Xiaoting Liu, Chong Wu, Mengru Wang, Jialing Gao, Zunfu Ke, Xiaojing Ma, Weiling He*

Redox Biology.2024.

DOI：10.1016/j.redox.2024.103349

MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis

Yuqin Di#, Xiang Zhang, Xiangqiong Wen, Jiale Qin, Lvlan Ye, Youpeng Wang, Mei Song*, Ziyang Wang*, Weiling He*

Advanced Science.2024.

DOI：10.1002/advs.202402795 Abstract

Prognostic and predictive value of examined lymph node count in stage III colorectal cancer: a population based study

Ran Wei#, Zifan Zheng#, Qinghai Li#, Yan Qian, Chong Wu, Yin Li, Mian Wang, Jianhui Chen, Weiling He*

World J Surg Oncol.2024.22(1):155

DOI：10.1186/s12957-024-03404-7

Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities

Lulu Chen#, Shuting Huang, Xiaoxue Wu, Weiling He*, Mei Song*

Clinical and Translational Medicine.2024.14(7):e1750

DOI：10.1002/ctm2.1750

Metabolism-regulated ferroptosis in cancer progression and therapy

Lvlan Ye#, Xiangqiong Wen#, Jiale Qin, Xiang Zhang, Youpeng Wang, Ziyang Wang, Ti Zhou*, Yuqin Di*, Weiling He*

Cell Death & Disease.2024.15(3):196

DOI：10.1038/s41419-024-06584-y

A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy

Jing Liu#, Jie Zhang#, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu*, Xianglong Hu*, Weiling He*

Biomater Sci.2024.12(10):2614-2625

DOI：10.1039/d4bm00003j

MEK-mediated CHPF2 phosphorylation promotes colorectal cancer cell proliferation and metastasis by activating NF-κB signaling

Xiangqiong Wen#, Jiale Qin, Xiang Zhang, Lvlan Ye, Youpeng Wang, Ranran Yang, Yuqin Di*, Weiling He*, Ziyang Wang*

CANCER LETTERS.2024.

DOI：10.1016/j.canlet.2024.216644

METTL3 promotes cellular senescence of colorectal cancer via modulation of CDKN2B transcription and mRNA stability

Zhuojia Chen#, Jiawang Zhou, You Wu, Feng Chen, Jianing Li, Lijun Tao, Yifan Tian, Haoran Wang, Jiexin Li, Zigang Li, Weiling He*, Kun Zhang*, Hongsheng Wang*

ONCOGENE.2024.43(13):976-991

DOI：10.1038/s41388-024-02956-y

Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

Chunliu Huang#, Xuefei Wang, Yingzhao Wang, Yongyi Feng, Xiumei Wang, Shan Chen, Peidong Yan, Jing Liao, Qi Zhang, Chengzhou Mao, Yang Li, Lixiang Wang, Xinyu Wang, Wei Yi, Weibin Cai, Shoudeng Chen, Ni Hong*, Weiling He*, Jun Chen*, Wenfei Jin*

Nat Cancer.2024.5(3):500-516

DOI：10.1038/s43018-023-00691-z

Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine

Yanhong Su#, Bing Liu, Binghan Wang, Leung Chan, Chan Xiong, Ligong Lu, Xuanjun Zhang*, Meixiao Zhan*, Weiling He*

Small.2024.20(25):e2310342

DOI：10.1002/smll.202310342

ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression

Yuqin Di#, Ziyang Wang#*, Jing Xiao#, Xiang Zhang#, Lvlan Ye, Xiangqiong Wen, Jiale Qin, Ligong Lu*, Xiongjun Wang*, Weiling He*

Science Advances.2024.10(38):eadp0719

DOI：10.1126/sciadv.adp0719

Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers

Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He*

Bioactive Materials.2023.

DOI：10.1016/j.bioactmat.2023.10.003

Isothermal Amplification-Based Detection of Single-Base RNA N6-Methyladenosine

Ke Zhong, You Wu, Jiangli Zhou, Xianyuan Yang, Cheng Yi, Lichen Ge, Zigang Li, Weiling He*, Jie Cao, Guanmin Jiang, Hongsheng Wang, Jiexin Li

ANALYTICAL CHEMISTRY.2023.95(51):18821-18827

DOI：10.1021/acs.analchem.3c03961

Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug

Jialing Gao, Xiaoxue Wu, Shuting Huang, Ziyi Zhao, Weiling He*, Mei Song

Redox Biology.2023.

DOI：10.1016/j.redox.2023.102891 Abstract

Biological informed graph neural network for tumor mutation burden prediction and immunotherapy-related pathway analysis in gastric cancer

Chuwei Liu, Arabella H Wan, Heng Liang, Lei Sun, Jiarui Li, Ranran Yang, Qinghai Li, Ruibo Wu, Kunhua Hu, Yuedong Yang, Shirong Cai, Guohui Wan, Weiling He*

Comput Struct Biotechnol J.2023.

DOI：10.1016/j.csbj.2023.09.021

Analgesic and potentiated photothermal therapy with ropivacaine-loaded hydrogels

Jiqian Zhang, Shasha Zhu, Mingxu Zhao, Mengni Zhou, Xiaoling Zhu, Xin Qing, Zhilai Yang, Pengfei Wei, Guoying Zhang, Weiling He*, Yongqiang Yu, Xuesheng Liu

Theranostics.2023.13(7):2226-2240

DOI：10.7150/thno.81325

Emerging insights into mechanisms of trastuzumab resistance in HER2-positive cancers

Xiaoxue Wu, Shuting Huang, Weiling He*, Mei Song

Int Immunopharmacol.2023.

DOI：10.1016/j.intimp.2023.110602

New insights into the correlations between circulating tumor cells and target organ metastasis

Qinru Zhan#, Bixia Liu#, Xiaohua Situ#, Yuting Luo, Tongze Fu, Yanxia Wang, Zhongpeng Xie, Lijuan Ren, Ying Zhu*, Weiling He*, Zunfu Ke*

Signal Transduct Target Ther.2023.8(1):465

DOI：10.1038/s41392-023-01725-9

Glutamate dehydrogenase1 supports HIF-1α stability to promote colorectal tumorigenesis under hypoxia

Kunhua Hu#, Yufeng Ding#, Hongwen Zhu#, Xiaoqian Jing, Weiling He*, Hua Yu*, Xiongjun Wang*

EMBO JOURNAL.2023.42(12):e112675

DOI：10.15252/embj.2022112675

N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis

Ziyou Lin, Arabella H Wan, Lei Sun, Heng Liang, Yi Niu, Yuan Deng, Shijia Yan, Qiao-Ping Wang, Xianzhang Bu, Xiaolei Zhang, Kunhua Hu, Guohui Wan, Weiling He*

MOLECULAR THERAPY.2023.31(2):517-534

DOI：10.1016/j.ymthe.2022.10.012

The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity

Yuqin Di, Xiaoqian Jing, Kunhua Hu, Xiangqiong Wen, Lvlan Ye, Xiang Zhang, Jiale Qin, Jinning Ye, Run Lin, Ziyang Wang, Weiling He*

Drug Resist Updat.2023.

DOI：10.1016/j.drup.2022.100909

Erratum: N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming: Erratum

Zhuojia Chen, Long Wu, Jiawang Zhou, Xinyao Lin, Yanxi Peng, Lichen Ge, Cheng-Ming Chiang, Hui Huang, Hongsheng Wang, Weiling He*

Theranostics.2023.13(12):3964-3965

DOI：10.7150/thno.85930

RNA m6A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin

Jiexin Li, Guoyou Xie, Yifan Tian, Wanglin Li, Yingmin Wu, Feng Chen, Yu Lin, Xinyao Lin, Shannon Wing-Ngor Au, Jie Cao, Weiling He, Hongsheng Wang

MOLECULAR THERAPY.2022.

DOI：10.1016/j.ymthe.2022.01.019

The Effect of Oxidative Phosphorylation on Cancer Drug Resistance

Ziyi Zhao, Yong Mei, Ziyang Wang, Weiling He*

Cancers (Basel).2022.15(1):62

DOI：10.3390/cancers15010062

Predictive Value of Circulating Tumor Cells Based on Subtraction Enrichment for Recurrence Risk in Stage II Colorectal Cancer

Lili Chen, Wenpeng Zhou, Ziyin Ye, Xiaoming Zhong, Jianwen Zhou, Shaohong Chen, Wei Liu, Yu Sun, Lijuan Ren, Xiaojun Tan, Ji Cui, Zhirong Zeng, Weiling He, Zunfu Ke

ACS Appl Mater Interfaces.2022.14(31):35389-35399

DOI：10.1021/acsami.2c08560

Engineering cancer cell membrane-camouflaged metal complex for efficient targeting therapy of breast cancer

Xiaoying Li, Yanzi Yu, Qi Chen, Jiabao Lin, Xueqiong Zhu, Xiaoting Liu, Lizhen He, Tianfeng Chen, Weiling He*

J Nanobiotechnology.2022.20(1):401

DOI：10.1186/s12951-022-01593-5

Correction: Biofunctional Janus particles promote phagocytosis of tumor cells by macrophages

Ya-Ru Zhang, Jia-Qi Luo, Jia-Xian Li, Qiu-Yue Huang, Xiao-Xiao Shi, Yong-Cong Huang, Kam W Leong, Wei-Ling He*, Jin-Zhi Du

Chemical Science.2022.13(27):8204

DOI：10.1039/d2sc90135h

N6-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis

Feng Chen, Zhuojia Chen, Tao Guan, Yan Zhou, Lichen Ge, Haisheng Zhang, Yingmin Wu, Guan-Min Jiang, Weiling He, Jiexin Li, Hongsheng Wang

CANCER RESEARCH.2021.

DOI：10.1158/0008-5472.CAN-20-3779

Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

Yi Niu, Ziyou Lin, Arabella Wan, Lei Sun, Shijia Yan, Heng Liang, Siyue Zhan, Dongshi Chen, Xianzhang Bu, Peiqing Liu, Ceshi Chen, Weiling He, Xiongbin Lu, Guohui Wan

HEPATOLOGY.2021.74(3):1461-1479

DOI：10.1002/hep.31846

Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers

Qinghai Li, Weiling He*, Guohui Wan

Front Oncol.2021.

DOI：10.3389/fonc.2020.586789

RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer

Lei Sun, Arabella Wan, Zhuolong Zhou, Dongshi Chen, Heng Liang, Chuwei Liu, Shijia Yan, Yi Niu, Ziyou Lin, Siyue Zhan, Shanfeng Wang, Xianzhang Bu, Weiling He, Xiongbin Lu, Anlong Xu, Guohui Wan

GUT.2021.70(9):1698-1712

DOI：10.1136/gutjnl-2020-320652

RNA m6A methylation regulates sorafenib resistance in liver cancer through FOXO3‐mediated autophagy

Ziyou Lin, Yi Niu, Arabella Wan, Dongshi Chen, Heng Liang, Xijun Chen, Lei Sun, Siyue Zhan, Liutao Chen, Chao Cheng, Xiaolei Zhang, Xianzhang Bu, Weiling He, Guohui Wan

EMBO JOURNAL.2020.

DOI：10.15252/embj.2019103181

Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory T-cell Survival in Gastric Adenocarcinoma

Run Lin, Hui Zhang, Yujie Yuan, Qiong He, Jianwen Zhou, Shuhua Li, Yu Sun, Daniel Y Li, Hai-Bo Qiu, Wei Wang, Zhehong Zhuang, Bin Chen, Yonghui Huang, Chuwei Liu, Yingzhao Wang, Shirong Cai, Zunfu Ke, Weiling He

Cancer Immunology Research.2020.

DOI：10.1158/2326-6066.CIR-19-0702

Biofunctional Janus particles promote phagocytosis of tumor cells by macrophages

Ya-Ru Zhang, Jia-Qi Luo, Jia-Xian Li, Qiu-Yue Huang, Xiao-Xiao Shi, Yong-Cong Huang, Kam W. Leong, Wei-ling He, Jin-Zhi Du

Chemical Science.2020.

DOI：10.1039/d0sc01146k

A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy against liver cancer

Dan Huang, Haitao Dai, Keyu Tang, Bin Chen, Hongzhang Zhu, Dubo Chen, Nan Li, Yingzhao Wang, Chuwei Liu, Yonghui Huang, Jianyong Yang, Chao Zhang, Run Lin, Weiling He

Nanoscale.2020.

DOI：10.1039/d0nr04592f

N6 -methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming

Zhuojia Chen, Long Wu, Jiawang Zhou, Xinyao Lin, Yanxi Peng, Lichen Ge, Cheng-Ming Chiang, Hui Huang, Hongsheng Wang, Weiling He

Theranostics.2020.

DOI：10.7150/thno.40144

Association of Preoperative Serum Carcinoembryonic Antigen and Gastric Cancer Recurrence: A Large Cohort Study

Qinbo Cai, Wen Zhou, Jin Li, Xinde Ou, Chuangqi Chen, Shirong Cai, Weiling He*, Jianbo Xu, Yulong He

Journal of Cancer.2020.

DOI：10.7150/jca.47899 Abstract

Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance

Qing-Hai Li, Ying-Zhao Wang, Jian Tu, Chu-Wei Liu, Yu-Jie Yuan, Run Lin, Wei-Ling He, Shi-Rong Cai, Yu-Long He, Jin-Ning Ye

Gastroenterol Rep (Oxf).2020.8(3):179-191

DOI：10.1093/gastro/goaa026

Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

Kaitao Yuan, Jinning Ye, Zhenguo Liu, Yufeng Ren, Weiling He*, Jianbo Xu, Yulong He, Yujie Yuan

J Exp Clin Cancer Res.2020.39(1):9

DOI：10.1186/s13046-019-1514-3

低氧诱导的HIF-1α对结肠癌细胞生长代谢的影响及其调控机制

weiling He#

常用医学杂志.2020.

A polyethylenimine-based diazeniumdiolate nitric oxide donor accelerates wound healing

Yan Zhang, Keyu Tang, Bin Chen, Su Zhou, Nan Li, Chuwei Liu, Jianyong Yang, Run Lin, Tao Zhang, Weiling He

Biomaterials Science.2019.

DOI：10.1039/c8bm01519h

Three-dimensional nanostructured substrates enable dynamic detection of ALK-rearrangement in circulating tumor cells from treatment-naive patients with stage III/IV lung adenocarcinoma

Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang, Zun-fu Ke

Journal of Translational Medicine.2019.

DOI：10.1186/s12967-019-1779-5

Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma

Weiling He#, Minzhi Hou, Hui Zhang, Chao Zeng, Shanyang He, Xinlin Chen, Manman Xu, Cong Sun, Wenting Jiang, Han Wang, […], Yangshan Chen, Jessica Cao, Chunlin Wang, Mengzhen Li, Yi Zhang, Liantang Wang, Jianhong Wang, Millicent Lin, Zunfu Ke

INTERNATIONAL JOURNAL OF CANCER.2018.

DOI：10.1002/ijc.31742

CD155T/TIGIT Signaling Regulates CD8+ T Cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer

Weiling He#, Hui Zhang, Fei Han, Xinlin Chen, Run Lin, Wei Wang, Haibo Qiu, Zhenhong Zhuang, Qi Liao, Weijing Zhang, Qinbo Cai, Yongmei Cui, Wenting Jiang, Han Wang, Zunfu Ke

CANCER RESEARCH.2017.

DOI：10.1158/0008-5472.CAN-17-0381